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About ATTR-CMAbout
ATTR-CM
Disease ImpactWhen to Rule Out ATTR-CMDiagnosing ATTR-CM
About VYNDAMAXAbout
VYNDAMAX
Mortality and Hospitalization6MWT/KCCQ-OS5-year DataHow VYNDAMAX WorksSafety Profile Study Design
DosingAccess & SupportAccess & SupportAccessing VYNDAMAXVyndaLinkResourcesResourcesEventsMaterialsVideos
Prescribing InformationPatient InformationIndication Patient Site
VYNDAMAX® (tafamidis)The only treatment for transthyretin cardiac amyloidosis* with a Class 1 recommendation in the ACC/AHA/HFSA Guidelines1†About ATTR cardiac amyloidosis

ATTR-CM is a progressive, fatal disease, so early diagnosis is critical2-5

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Is it time to rule out ATTR-CM?

It’s more common than you think2

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VYNDAMAX: Efficacy and safety profile

Proven to reduce all-cause mortality and CV-related hospitalization6

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Also known as transthyretin amyloid cardiomyopathy (ATTR-CM).As of November 2023, VYNDAMAX and VYNDAQEL are the only agents approved for ATTR cardiac amyloidosis recommended in the guidelines.Do you have patients with HFpEF in your practice?

Watch an in-depth video featuring peer perspectives from Dr Christopher Pray (St Clair Health, Pittsburgh, PA) and Dr Fernando Mendoza (UC Irvine, Irvine, CA) on the importance of ruling out ATTR cardiac amyloidosis in patients with heart failure

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Find out about ATTR-CM, VYNDAMAX, and access

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Dive deeper into ATTR-CM and VYNDAMAX data

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ACC=American College of Cardiology; AHA=American Heart Association; ATTR=transthyretin amyloidosis; CV=cardiovascular; HFSA=Heart Failure Society of America.Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(18):e876-e894.References:Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(18):e876-e894.Witteles RM, Bokhari S, Damy T, et al. Screening for transthyretin amyloid cardiomyopathy in everyday practice. JACC Heart Fail. 2019;7(8):709-716.Lane T, Fontana M, Martinez-Naharro A, et al. Natural history, quality of life, and outcome in cardiac transthyretin amyloidosis. Circulation. 2019;140(1):16-26.Maurer MS, Elliott P, Comenzo R, Semigran M, Rapezzi C. Addressing common questions encountered in the diagnosis and management of cardiac amyloidosis. Circulation. 2017;135(14):1357-1377.Maurer MS, Bokhari S, Damy T, et al. Expert consensus recommendations for the suspicion and diagnosis of transthyretin cardiac amyloidosis. Circ Heart Fail. 2019;12(9):e006075.Vyndaqel and Vyndamax [prescribing information]. New York, NY: Pfizer Inc; 2023.

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INDICATION AND LIMITATIONS OF USE VYNDAQEL and VYNDAMAX are indicated for the treatment of the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization.Please see Full Prescribing Information including Patient Information.
Important Safety InformationAdverse Reactions
In studies in patients with ATTR-CM, the frequency of adverse events in patients treated with VYNDAQEL® (tafamidis meglumine) was similar to placebo.

Specific Populations

Pregnancy: Based on findings from animal studies, VYNDAQEL and VYNDAMAX may cause fetal harm when administered to a pregnant woman.

Lactation: There are no available data on the presence of tafamidis in human milk, the effect on the breastfed infant, or the effect on milk production. Tafamidis is present in rat milk. When a drug is present in animal milk, it is likely the drug will be present in human milk. Breastfeeding is not recommended during treatment with VYNDAQEL and VYNDAMAX.
IndicationVYNDAQEL® (tafamidis meglumine) and VYNDAMAX are indicated for the treatment of the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization.

Please see Full Prescribing Information including Patient Information.