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About ATTR-CMAbout
ATTR-CMDisease ImpactWhen to Rule Out ATTR-CMDiagnosing ATTR-CMAbout VYNDAMAXAbout
VYNDAMAXMortality and Hospitalization6MWT/KCCQ-OS5-year DataHow VYNDAMAX WorksSafety Profile Study DesignDosingAccess & SupportAccess & SupportAccessing VYNDAMAXFree Trial ProgramResourcesResourcesEventsMaterialsVideos
Prescribing InformationPatient InformationIndication Patient Site
VYNDAMAX® (tafamidis) is the only once-daily capsule for ATTR cardiac amyloidosis* that offers1:Learn About VYNDAMAXProven efficacy

Reduction in CV mortality and CV-related hospitalizations1

LoadingPlacebo-like safety

A safety profile comparable to placebo1†

LoadingRobust body of evidence

5+ years of data across clinical trials and real-world evidence1-4

Loading*Also known as transthyretin amyloid cardiomyopathy, or ATTR-CM.†In clinical trials, the frequency of adverse events was similar to placebo.1Is it time to screen for ATTR-CM?

It’s more common than you think5

See the red flagsLoadingSee how VYNDAMAX works

Tafamidis is a disease-modifying therapy that selectively stabilizes TTR, helping to prevent the misfolding of TTR and the formation of amyloid fibrils.6,7

Learn moreLoading VYNDAMAX access support starts here: Partnering with you to support your patients’ ability to access their prescription.
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Loading VYNDAMAX Free Trial Program

Get eligible new patients started with a free 30-day trial
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Dive deeper into ATTR-CM and VYNDAMAX data

Download materials

Explore resources on ATTR-CM, VYNDAMAX, and access

ATTR=transthyretin amyloidosis; ATTR-CM=transthyretin amyloid cardiomyopathy; CV=cardiovascular; TTR=transthyretin.References:VYNDAQEL and VYNDAMAX [prescribing information]. New York, NY: Pfizer Inc; 2023.Elliott P, Drachman BM, Gottlieb SS, et al. Long-term survival with tafamidis in patients with transthyretin amyloid cardiomyopathy. Circ Heart Fail. 2022;15(1):e008193.Data on file. Pfizer Inc., New York, NY.Garcia-Pavia P, Kristen AV, Drachman B, et al; THAOS Investigators. Survival in a real-world cohort of patients with transthyretin amyloid cardiomyopathy treated with tafamidis: an analysis from the Transthyretin Amyloidosis Outcomes Survey (THAOS). J Card Fail. 2025;31(3):525-533.Witteles RM, Bokhari S, Damy T, et al. Screening for transthyretin amyloid cardiomyopathy in everyday practice. JACC Heart Fail. 2019;7(8):709-716.Maurer MS, Schwartz JH, Gundapaneni B, et al; ATTR-ACT Study Investigators. Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy. N Engl J Med. 2018;379(11):1007-1016.Tess DA, Maurer TS, Li Z, Bulawa C, Fleming J, Moody AT. Relationship of binding-site occupancy, transthyretin stabilisation and disease modification in patients with tafamidis-treated transthyretin amyloid cardiomyopathy. Amyloid. 2023;30(2):208-219.

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INDICATION AND LIMITATIONS OF USE VYNDAQEL and VYNDAMAX are indicated for the treatment of the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization.Please see Full Prescribing Information including Patient Information.
Important Safety InformationAdverse Reactions
In studies in patients with ATTR-CM, the frequency of adverse events in patients treated with VYNDAQEL® (tafamidis meglumine) was similar to placebo.

Specific Populations

Pregnancy: Based on findings from animal studies, VYNDAQEL and VYNDAMAX may cause fetal harm when administered to a pregnant woman.

Lactation: There are no available data on the presence of tafamidis in human milk, the effect on the breastfed infant, or the effect on milk production. Tafamidis is present in rat milk. When a drug is present in animal milk, it is likely the drug will be present in human milk. Breastfeeding is not recommended during treatment with VYNDAQEL and VYNDAMAX.IndicationVYNDAQEL® (tafamidis meglumine) and VYNDAMAX are indicated for the treatment of the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization.

Please see Full Prescribing Information including Patient Information.