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About ATTR-CMAbout
ATTR-CMDisease ImpactWhen to Rule Out ATTR-CMDiagnosing ATTR-CMAbout VYNDAMAXAbout
VYNDAMAXMortality and Hospitalization6MWT/KCCQ-OS5-year DataHow VYNDAMAX WorksSafety Profile Study DesignDosingAccess & SupportAccess & SupportAccessing VYNDAMAXPaying for VYNDAMAXResourcesResourcesEventsMaterialsVideos
Prescribing InformationPatient InformationIndication Patient Site
How VYNDAMAX WorksTafamidis is a disease-modifying therapy that inhibits cardiac amyloidosis by selectively stabilizing TTR1*
Tafamidis specifically targets TTR and fortifies the TTR tetramer to help preserve its natural function2,3
  • Stabilized TTR can continue to circulate naturally to perform critical biologic functions3
  • Biomarkers associated with heart failure (NT-proBNP and Troponin I) favored VYNDAQEL over placebo2
At the approved dose, tafamidis delivers near complete stabilization of TTR3†

*Relationship between TTR occupancy by tafamidis and TTR stabilization was evaluated analyzing data from ATTR-ACT using models of TTR concentrations in human plasma.3

†Near complete stabilization equates to a reduction in unbound TTR tetramer by >90%, the near maximum achievable degree for the class.3

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ATTR-ACT=Transthyretin Amyloidosis Cardiomyopathy Clinical Trial; NT-proBNP=N-terminal pro-B-type natriuretic peptide; TTR=transthyretin.
References: Maurer MS, Schwartz JH, Gundapaneni B, et al. Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy. N Engl J Med. 2018;379(11):1007-1016.VYNDAQEL and VYNDAMAX [prescribing information]. New York, NY: Pfizer Inc; 2023.Tess DA, Maurer TS, Li Z, Bulawa C, Fleming J, Moody AT. Relationship of binding-site occupancy, transthyretin stabilisation and disease modification in patients with tafamadis-treated transthyretin amyloid cardiomyopathy. Amyloid. 2023;30(2):208-219.
About VYNDAMAXEfficacy and safety outcomes
Review the clinical data
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INDICATION AND LIMITATIONS OF USE VYNDAQEL and VYNDAMAX are indicated for the treatment of the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization.Please see Full Prescribing Information including Patient Information.
Important Safety InformationAdverse Reactions
In studies in patients with ATTR-CM, the frequency of adverse events in patients treated with VYNDAQEL® (tafamidis meglumine) was similar to placebo.

Specific Populations

Pregnancy: Based on findings from animal studies, VYNDAQEL and VYNDAMAX may cause fetal harm when administered to a pregnant woman.

Lactation: There are no available data on the presence of tafamidis in human milk, the effect on the breastfed infant, or the effect on milk production. Tafamidis is present in rat milk. When a drug is present in animal milk, it is likely the drug will be present in human milk. Breastfeeding is not recommended during treatment with VYNDAQEL and VYNDAMAX.IndicationVYNDAQEL® (tafamidis meglumine) and VYNDAMAX are indicated for the treatment of the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization.

Please see Full Prescribing Information including Patient Information.